Yanwei Jia(Homepage)

Yanwei Jia

賈艷偉

Email:yanweijia

Phone:(+853) 8822-4451

Room Number:N21-3001ca

Assistant Professor

Contact Hour: Mon 10:00-11:00, Tue 10:00-11:00

 

Professional Experience

  • Assistant Professor, State-Key Lab. of Analog and Mixed-Signal VLSI, University of Macau (Jan. 2016 – present)
  • Postdoctoral Fellow, State-Key Lab. of Analog and Mixed-Signal VLSI, University of Macau (Jan. 2013 – Dec. 2015)
  • Research Scientist, Research Associate, Postdoctoral Fellow, Brandeis University, USA (May 2006 – Dec. 2011)
  • Research Fellow, National University of Singapore (Jan. 2006 – Apr. 2006)

Research

Research Interests

  • Automated point-of-care device for disease diagnostics
  • Digital microfluidics for biomedical applications
  • Novel PCR technology development

 

Teaching Experience

B.Sc. Courses

  • Fundamental Bio-Electricity (ECEN3004)

M.Sc. Courses

  • Special Topics in Biomedical Engineering (Session I)
  • Special Topics in Biomedical Engineering (Session II)

 

Funded Projects:

  1. Co-PI, FDCT 047/A1/2014, Electronic-automated Digital Microfluidic System for Disease diagnostics, MOP 3,290,000, 2015 - 2018.
  2. PI, FDCT 110/A3/2016, Integration of Digital & Channel Microfluidic Systems for High-throughput Drug Screening, MOP 1,923,000, 2017 – 2020.
  3. PI, SRG 2016-00072-AMSV, Digital Microfluidics for Disease Diagnostics, MOP 150,000, 2016 – 2019.
  4. PI, MYRG 2017-00022-AMSV, Intelligent-controlled Point-of-Care Fast Infectious Disease Diagnostic System, MOP 900,000, 2018 – 2020.
  5. PI, MYRG 2018-00114-AMSV, 3D Micro-structured Digital Microfluidic System with Closed-Loop Image Analysis for Cell Recognition in Precision Medicine Investigations, MOP 1,455,000, 2019 – 2021.
  6. PI, Guangzhou Science and Technology Innovation and Development of Special Funds, EF009/AMSV-JYW/2018/GSTIC, Development and Industrialization of Drug Resistant Tuberculosis Detection Kit and Equipment Based on Digital Microfluidic PCR and HRM Platform, RMB 700,000, Collaborating with DaAn Gene Ltd., 2018 – 2021.

AwardsTotal: 2
  1. 2. Yanwei Jia, "Innovation Prize", International Organization for Biological Crystallization (2008), , Jan-2008
  2. 1. Yanwei Jia, "Outstanding Mentor Award", Ministry of Education of Singapore (2004), Singapore, Jan-2004
Patents and Technology TransferTotal: 13
  1. 13. L. J. Wangh, J. E. Rice, N. Rice, Yanwei Jia, "Reagents and Methods for PCR", US PATENT, , Granted, No. 9758813, Sept 12, 2017
  2. 12. S. Fraden, H. Boukellal, Yanwei Jia, S. Selimovic, A. Rowat, J. Agresti, D. A. Weitz, "Manipulation of Fluids, Fluid Components and Reactions in Microfluidic Systems", US PATENT, , Granted, No. 9588025, March 7, 2017
  3. 11. Yanwei Jia, L. J. Wangh, J. A. Sanchez, J. Rice, "Detecting Nucleic Acid Variations within Populations of Genomes", US PATENT, , Granted, No. 9169514, Oct. 23. 2015
  4. 10. S. Fraden, H. Boukellal, Yanwei Jia, S. Selimovic, A. Rowat, J. Agresti, D. A. Weitz, "Manipulation of Fluids, Fluid Components and Reactions in Microfluidic Systems", US PATENT, , Granted, No. 9068699, June 30, 2015
  5. 9. L. J. Wangh, J. Rice, N. Rice, Yanwei Jia, "Reagents and Methods for PCR", US PATENT, , Granted, No. 9034605, May 19, 2015
  6. 8. S. Fraden, Yanwei Jia, H. Boukellal, S. Selimovic, A. Rowat, J. Agresti, D. A. Weitz, "Manipulation of Fluids, Fluid Components and Reactions in Microfluidic Systems", US PATENT, , Granted, No. 8592221, Nov. 23, 2013
  7. 7. X. Y. Liu, Yanwei Jia, "Method for Prediction de novo Biomacromolecule Crystallization Conditions and for Crystallization of the Same", SINGAPORE PATENT, No. 124995 (WO2005/080422), , Sept 28, 2007
  8. 6. Cheng Dong, Tianlan Chen, Jie Gao, Yanwei Jia, Pui In Mak, Mang I Vai, R. P. Martins, "Cooperative-electrode Driving Technique for Droplet-velocity Improvement of Digital Microfluidic Systems", US PATENT, Reference No. US 14/683,316, , Apr 10, 2015
  9. 5. J. Rice, Yanwei Jia, L. J. Wangh, "Combination of dsDNA Binding Dye and Probes for Characterization of ssDNA Sequences", US PATENT, Reference No. 61/702,019, , Sep. 17, 2012
  10. 4. L. J. Wangh, Yanwei Jia, C. Hartshorn, "Methods for Making Embryonic Cells, Embryos, and Animals Sensitized to Stress", US PATENT, Reference No. PCT/US10/40701, , July 1, 2010
  11. 3. Jie Gao, Tianlan Chen, Cheng Dong, Yanwei Jia, Pui In Mak, Mang I Vai, R. P. Martins, "Electronic Module for Real-time Droplet-position Sensing and Driving in Digital Microfluidic System", US PATENT, , Granted Number: 9,751,083,, Sept 5, 2017
  12. 2. Tianlan Chen, Cheng Dong, Jie Gao, Yanwei Jia, Pui In Mak, Mang I Vai, R. P. Martins, "Electrode-voltage Waveform for Droplet-velocity and Chip-lifetime Improvements of Digital Microfluidic Systems", US PATENT, , Granted Number: 9,808,800, 07 Nov, 2017
  13. 1. Yanwei Jia, J. A. Sanchez, J. Rice, L. J. Wangh, "Methods and Kits for Detecting Nucleic Acid Mutants in Wild-Type Populations", US PATENT, Reference No. 20160040242, , Oct, 2015
Journals and MagazinesTotal: 25
  1. 25. Liang Wan, Jie Gao, Tianlan Chen, Cheng Dong, Haoran Li, Yan-Zi Wen, Zhao-Rong Lun, Yanwei Jia, Pui In Mak, R. P. Martins, "LampPort: a handheld digital microfluidic device for loop-mediated isothermal amplification (LAMP)", Biomedical Microdevices, Jan-2019.
  2. 24. Zhai Jiao, Yanwei Jia, L. N. Zhao, Q. Yuan, F. P. Gao, X. C. Zhang, P. J. Cai, L. Gao, J. J. Gao, S. H. Yi, Z. F. Chai, Y. L. Zhao, X. Y. Gao, "Turning on/off the anti-tumor effect of the Au cluster via atomically controlling its molecular size", ACS Nano, Apr-2018.
  3. 23. Liang Wan, Tianlan Chen, Jie Gao, Cheng Dong, Ada Hang-Heng Wong, Yanwei Jia, Pui In Mak, C. X. Deng, R. P. Martins, "A digital microfluidic system for loop-mediated isothermal amplification and sequence specific pathogen detection", Scientific Reports, Nov-2017.
  4. 22. A. H. H. Wong, Haoran Li, Yanwei Jia, Pui In Mak, R. P. Martins, Y. Liu, C. M. Vong, H. C. Won, P. K. Wong, H. T. Wang, H. Sun, C. X. Deng, "Drug screening of cancer cell lines and human primary tumors using droplet microfluidics", Scientific Reports, Aug-2017.
  5. 21. C. Xu, Y. L. Wang, C. Y. Zhang, Yanwei Jia, Y. J. Luo, X. Y. Gao, "AuGd integrated nanoprobes for optical/MRI/CT triple-modal in vivo tumor imaging", RSC Nanoscale, Mar-2017.
  6. 20. Cheng Dong, Yanwei Jia, Jie Gao, Tianlan Chen, Pui In Mak, Mang I Vai, R. P. Martins, "A 3D microblade structure for precise and parallel droplet splitting on digital microfluidic chips", Lab on a Chip, Feb-2017.
  7. 19. Tianlan Chen, Yanwei Jia, Cheng Dong, Jie Gao, Pui In Mak, R. P. Martins, "Sub-7-second genotyping of single-nucleotide polymorphism by high-resolution melting curve analysis on a thermal digital microfluidic device", Lab on a Chip, Jan-2016.
  8. 18. Jie Gao, Tianlan Chen, Cheng Dong, Yanwei Jia, Pui In Mak, Mang I Vai, R. P. Martins, "Adhesion Promoter for Multi-dielectric-layer on Digital Microfluidic Chip", RSC Advances, 2015, May-2015.
  9. 17. Cheng Dong, Tianlan Chen, Jie Gao, Yanwei Jia, Pui In Mak, Mang I Vai, R. P. Martins, "On the Droplet Velocity and Electrode Lifetime of Digital Microfluidics: Voltage Actuation Techniques and Comparison", Springer Microfluidics and Nanofluidics, Apr-2015.
  10. 16. Tianlan Chen, Cheng Dong, Jie Gao, Yanwei Jia, Pui In Mak, Mang I Vai, R. P. Martins, "Natural Discharge after Pulse and Cooperative Electrodes to Enhance Droplet Velocity in Digital Microfluidics", AIP Advances, Apr-2014.
  11. 15. Yanwei Jia, J. A. Sanchez, L. J. Wangh, "Kinetic Hairpin Oligonucleotide Blockers for Selective Amplification of Rare Mutations", Scientific Reports, Jan-2014.
  12. 14. Yanwei Jia, Pui In Mak, C. Massey, R. P. Martins, L. J. Wangh, "Construction of a microfluidic chip, using dried-down reagents, for LATE-PCR amplification and detection of single-stranded DNA", Lab on a Chip, Jan-2013.
  13. 13. Yanwei Jia, C. Hartshorn, O. Hartung, L. J. Wangh, "Heat Shock Memory in Preimplantation Mouse Embryos", Fertility and Sterility, Jan-2010.
  14. 12. Yanwei Jia, A. Osborne, J. E. Rice, L. J. Wangh, "Dilute-‘N’-Go Dideoxy Sequencing of All DNA Strands Generated in Multiplexed LATE-PCR Assays", Nucleic Acids Research, Jan-2010.
  15. 11. S. Selimovic, Yanwei Jia, S. Fraden, "Measuring the Nucleation Rate of Lysozyme Using Microfluidics", Crystal Growth & Design, Jan-2009.
  16. 10. H. Boukellal, S. Selimovic, Yanwei Jia, G. Cristobal, S. Fraden, "Simple, Robust Storage of Drops and Fluids in a Microfluidic Device", Lab on a Chip, Jan-2009.
  17. 9. C. Hartshorn, A. Anshelevich, Yanwei Jia, L. J. Wangh, "Early Onset of Heat-Shock Response in Mouse Embryos Revealed by Quantification of Stress-Inducible hsp70i RNA", Gene Regulation and Systems Biology, Jan-2007.
  18. 8. J.-uk Shim, G. Cristobal, D. Link, T. Thorsen, Yanwei Jia, K. Piatelli, S. Fraden, "Control and Measurement of the Phase Behavior of Aqueous Solutions Using Microfluidics", Journal of the American Chemical Society, Jan-2007.
  19. 7. Yanwei Jia, X. Y. Liu, "From Surface Self-assembly to Crystallization: Prediction of Protein Crystallization Conditions", Journal of Physical Chemistry B, Jan-2006.
  20. 6. Yanwei Jia, X. Y. Liu, "Self-assembly of Protein at Aqueous Solution Surface in Correlation to Protein Crystallization", Applied Physics Letters, Jan-2005.
  21. 5. Yanwei Jia, X. Y. Liu, "Prediction of Protein Crystallization Based on Interfacial and Diffusion Kinetics", Applied Physics Letters, Jan-2005.
  22. 4. Yanwei Jia, J. Narayanan, X. Y. Liu, Y. Liu, "Investigation of the Mechanism of Crystallization of Soluble Protein in the Presence of Nonionic Surfactant", Biophysical Journal, Jan-2005.
  23. 3. Q. H. Liu, Yanwei Jia, W. H. Qi, Z. C. Ou-Yang, "Static Bistable Helices in Generalized Helfrich Elastic Theory of a Chiral Filament", Physics Letters A, Jan-2003.
  24. 2. Yanwei Jia, Q. H. Liu, "New Method to Solve the Nonlinear Equation of Membrane", Journal of Hunan University, Jan-2002.
  25. 1. Yanwei Jia, Q. H. Liu, X. H. Peng, X. Wang, K. C. Shen, "The Quantum-classical Correspondence of Matrix Elements of Hydrogen Atom’s Inverse Radius in Heisenberg Principle", Acta Physica Sinica, Jan-2002.
Conference Papers and PresentationsTotal: 9
  1. 9. Yanwei Jia, "Development of Digital Microfluidic Systems for Disease Diagnostics", Oral Presentation BIT’s 8th World Convention, Macau, Nov-2017.
  2. 8. Liang Wan, Tianlan Chen, Jie Gao, Cheng Dong, Yanwei Jia, Pui In Mak, R. P. Martins, "Digital Microfluidic Platform for False-Positive-Free Loop-Mediated Isothermal Amplification", International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), paper M167g, Oct-2017.
  3. 7. Jie Gao, Liang Wan, Yanwei Jia, Tianlan Chen, Cheng Dong, Haoran Li, Shun Liu, Pui In Mak, R. P. Martins, "A Thermal Digital Microfluidic Device and Its Application to Disease Diagnostics", Lab on a Chip International Symposium: Droplet-based Microfluidics, Hang Zhou, China, Nov-2016.
  4. 6. Liang Wan, Tianlan Chen, Jie Gao, Cheng Dong, Yanwei Jia, Pui In Mak, R. P. Martins, "Digital microfluidic system for LAMP-based detection of Trypanosoma brucei using molecular beacon probes", Lab on a Chip International Symposium: Droplet-based Microfluidics, Hang Zhou, China, Nov-2016.
  5. 5. Cheng Dong, Yanwei Jia, Tianlan Chen, Jie Gao, Liang Wan, Pui In Mak, Mang I Vai, R. P. Martins, "Precise Droplet Splitting on Digital Microfluidic Chip with Blade Structures”,", MicroTAS, Dublin, Ireland, Oct-2016.
  6. 4. Tianlan Chen, Yanwei Jia, Cheng Dong, Jie Gao, Liang Wan, Pui In Mak, R. P. Martins, "A Calibration-free Thermal Digital Microfluidic Device for Ultrafast DNA Melting Curve Analysis", MicroTAS, Dublin, Ireland, Oct-2016.
  7. 3. Cheng Dong, Yanwei Jia, Tianlan Chen, Liang Wan, Pui In Mak, Mang I Vai, R. P. Martins, "Digital Microfluidic Chip with Blade Structures for Precise Droplet Splitting", International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), paper W108f, Jul-2016.
  8. 2. Tianlan Chen, Jie Gao, Cheng Dong, Yanwei Jia, Pui In Mak, R. P. Martins, "Digital Microfluidic System with Intelligent Control for Ultrafast DNA Analysis", Oral Presentation at the 8th International Symposium on Microchemistry and Microsystems (ISMM), Hong Kong, May-2016.
  9. 1. Hang-Heng Wong, Yanwei Jia, Chuxia Deng, "Detection of cellular drug response on microfluidic chip for personalized cancer therapy", The 8th International Symposium on Microchemistry and Microsystems (ISMM), Hong Kong, May-2016.



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